As Hsien observes, everyone’s blogging about their $1000 personal variomes…so I confess to feeling a little sheepish posting yet another breathless update about the PGP. On the other hand, it beats wrapping Christmas presents…
- The Church lab-invented, Danaher-manufactured Polonator — the high-speed sequencing platform that will, um, soon be used to sequence our 20,000 genes — is now available for purchase (hurry and and you can leave it under the tree…some assembly required…).
- The Affymetrix SNP chip has been done on most of the PGP-10. I know you’re all dying to know my relative risk for restless legs syndrome.
- The Church/Danaher team has put its hat in the ring for the X-Prize. This means the PGP-10 will almost certainly have their complete genomes sequenced in the next 1-2 years. Which means we won’t have to scratch that check for $350k. Which means more money left over to buy my kids bobblehead dolls. Yay!
- The PGP is also exploring the transcriptome. George reports that his lab has improved its protocol for converting skin-derived fibroblasts to pluripotent stem cells. For those who want to know why: “We have been doing allele-specific quantitative RNA sequencing assays, since we feel that this is complementary to sequencing the non-coding regions and in many ways preferable to standard RNA assays of tissues from individuals. This provides an assay for nearly all cis-elements (enhancers, promoters, splicing signals, RNA termination, poly-A sites, etc.).”
- In the next couple of months, I expect the PGP-10 will reconvene in Boston, at which time we will:
Things may be quiet here for a while (yes yes, what else is new?). For now, Nat, Frank and I would like to toast you with a wish for peace on earth and good will toward almost everyone…