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DNA Replication-Transcription Conflicts Do Not Significantly Contribute to Spontaneous Mutations Due to Replication Errors in Escherichia coli

Encounters between DNA replication and transcription may cause genomic disruption, notably when the 2 meet head-on. Whether or not these conflicts produce level mutations is debated. This paper presents detailed analyses of a big assortment of mutations generated throughout mutation accumulation experiments with mismatch restore (MMR)-defective Escherichia coli. With MMR absent, mutations are primarily on […]