genomeboy

Synthesis of Polyanionic C5-Modified 2′-Deoxyuridine and 2′-Deoxycytidine-5′-Triphosphates and Their Properties as Substrates for DNA Polymerases

Modified 2′-deoxyribonucleotide triphosphates (dNTPs) have widespread purposes in each current and rising biomolecular applied sciences. For such purposes it’s a necessary requirement that the modified dNTPs be substrates for DNA polymerases. To this point very few examples of C5-modified dNTPs bearing negatively charged performance have been described, although such nucleotides would possibly doubtlessly be worthwhile […]

genomeboy

Nanoparticle Superlattices through Template-Encoded DNA Dendrimers

The chemical interactions that result in the emergence of hierarchical buildings are sometimes extremely advanced and tough to program. Herein, the synthesis of a sequence of superlattices based mostly upon 30 totally different structurally reconfigurable DNA dendrimers is reported, every of which presents a well-defined variety of single-stranded oligonucleotides (i.e., sticky ends) on its floor. […]