Selenium-atom-modified thymidine enhances the specificity and sensitivity of DNA polymerization and detection
Nucleobase mismatches can jeopardize DNA polymerization specificity, inflicting mutations and errors in DNA replication and detection. Herein we report the primary synthesis of novel 2-Se-thymidine triphosphate (SeTTP), describe the single-selenium atom-specific modification technique (SAM) towards T/G mismatches, and exhibit SAM-assisted polymerization and detection with a lot greater specificity and sensitivity.
SAM can successfully suppress the formation of non-specific merchandise in DNA polymerization and detection. Thus, SAM enhances the specificity of DNA synthesis by roughly 10 000 fold, and in flip, it permits the detection of scientific COVID-19 viral RNA in low copy numbers (single-digit copies), whereas the standard RT-qPCR doesn’t.

Remedy of Triple Unfavourable Cell Traces with Olaparib to Block DNA Restore
A Versatile One-Step Aggressive Fiber Optic Floor Plasmon Resonance Bioassay Enabled by DNA Nanotechnology
- On this method, we enabled one-step aggressive detection and will obtain vital alerts, unbiased of the burden of the goal molecules, with out requiring labeling or preprocessing steps. This was demonstrated for the detection of a small molecule (ATP), protein (thrombin), and ssDNA goal, thereby reaching detection limits of 72 μM, 36 nM, and 30 nM respectively and proving the generalizability of the proposed bioassay.
- Moreover, goal detection was efficiently achieved in 10-fold diluted plasma, which demonstrated the applicability of the assay in biologically related matrices. Altogether, the developed one-step aggressive FO-SPR bioassay opens up prospects for the detection of low-molecular-weight targets in a quick and simple method.
A PCR-amplified transgene fragment flanked by a single copy of a truncated inverted terminal repeat for recombinant adeno-associated virus manufacturing prevents pointless plasmid DNA packaging
Recombinant Salmonella Typhi S. Typhi OMP Protein, His, E.coli-100ug |
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QP13384-100ug | EnQuireBio | 100ug | EUR 261.6 |
Recombinant Salmonella Typhi S. Typhi OMP Protein, His, E.coli-500ug |
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QP13384-500ug | EnQuireBio | 500ug | EUR 795.6 |
Recombinant Salmonella Typhi S. Typhi HylE Protein, His, E.coli-100ug |
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QP13383-100ug | EnQuireBio | 100ug | EUR 241.2 |
Recombinant Salmonella Typhi S. Typhi HylE Protein, His, E.coli-500ug |
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QP13383-500ug | EnQuireBio | 500ug | EUR 555.6 |
Recombinant Salmonella Typhi S. Typhi OMP 52kDa Protein, His, E.coli-1mg |
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QP13385-1mg | EnQuireBio | 1mg | EUR 795.6 |
Recombinant Salmonella Typhi S. Typhi OMP 52kDa Protein, His, E.coli-100ug |
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QP13385-100ug | EnQuireBio | 100ug | EUR 241.2 |
Recombinant Salmonella Typhi S. Typhi OMP 52kDa Protein, His, E.coli-500ug |
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QP13385-500ug | EnQuireBio | 500ug | EUR 555.6 |
Recombinant Salmonella typhi spaQ Protein (aa 1-86) |
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VAng-Wyb0630-inquire | Creative Biolabs | inquire | Ask for price |
Description: Salmonella typhi Surface presentation of antigens protein SpaQ, recombinant protein. |
Salmonella Typhi Protein |
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abx061484-01ml | Abbexa | 0.1 ml | EUR 661.2 |
Salmonella typhi DNA-binding protein HU-beta (hupB) |
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1-CSB-EP363134SWW | Cusabio |
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Description: Recombinant Salmonella typhi DNA-binding protein HU-beta(hupB) expressed in E.coli |
Colwellia psychrerythraea DNA polymerase IV (dinB) |
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1-CSB-EP676401CBAB | Cusabio |
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Description: Recombinant Colwellia psychrerythraea DNA polymerase IV(dinB) expressed in E.coli |
Colwellia psychrerythraea DNA polymerase IV (dinB) |
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1-CSB-EP676401CBABe1 | Cusabio |
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Description: Recombinant Colwellia psychrerythraea DNA polymerase IV(dinB) expressed in E.coli |
Salmonella typhi pagC Protein |
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abx069935-1mg | Abbexa | 1 mg | EUR 2431.2 |
Salmonella Typhi IgG ELISA Kit |
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E4678-100 | Biovision | each | EUR 810 |
Salmonella Typhi IgM ELISA Kit |
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E4679-100 | Biovision | each | EUR 810 |
Salmonella Typhi Flagellin Protein |
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abx061568-1mg | Abbexa | 1 mg | EUR 2114.4 |
Inactivated Salmonella Typhi Antigen |
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VAng-Lsx04607-100L | Creative Biolabs | 100 µL | EUR 1033.2 |
Description: Salmonella Typhi inactivated native antigen. |
Recombinant Salmonella typhisuis spaQ Protein (aa 1-86) |
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VAng-Wyb0626-inquire | Creative Biolabs | inquire | Ask for price |
Description: Salmonella typhisuis Surface presentation of antigens protein SpaQ, recombinant protein. |
Salmonella typhi Protein viaA (viaA) |
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1-CSB-RP165194Ba | Cusabio |
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Description: Recombinant Salmonella typhi Protein viaA(viaA),partial expressed in E.coli |
Salmonella Typhi H Antigen Protein |
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abx061569-1mg | Abbexa | 1 mg | EUR 627.6 |
Recombinant Salmonella Typhimurium Uridine phosphorylase |
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7-03784 | CHI Scientific | 10µg | Ask for price |
Recombinant Salmonella Typhimurium Uridine phosphorylase |
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7-03785 | CHI Scientific | 50µg | Ask for price |
Recombinant Salmonella Typhimurium Uridine phosphorylase |
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7-03786 | CHI Scientific | 1mg | Ask for price |
Salmonella Typhimurium Uridine phosphorylase (Recombinant) |
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20-abx073038 | Abbexa |
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Mouse antibody for Salmonella typhi LPS |
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6345 | Virostat | 100 ug | EUR 386.26 |
Description: This is purified Mouse monoclonal antibody against Salmonella typhi LPS for WB, ELISA. |
Human Salmonella Typhi Antigen ELISA Kit |
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abx053374-96tests | Abbexa | 96 tests | EUR 801.6 |
Recombinant (E.Coli) Uridine phosphorylase Salmonella typhimurium |
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RP-429 | Alpha Diagnostics | 10 ug | EUR 270 |
Salmonella typhi Lipopolycaccharide (LPS) Antibody |
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abx024121-1mg | Abbexa | 1 mg | EUR 1262.4 |