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DNA Replication-Transcription Conflicts Do Not Significantly Contribute to Spontaneous Mutations Due to Replication Errors in Escherichia coli

Encounters between DNA replication and transcription may cause genomic disruption, notably when the 2 meet head-on. Whether or not these conflicts produce level mutations is debated. This paper presents detailed analyses of a big assortment of mutations generated throughout mutation accumulation experiments with mismatch restore (MMR)-defective Escherichia coli. With MMR absent, mutations are primarily on […]

Nanopore-Based Single-Molecule Investigation of DNA Sequences with Potential to Form i-Motif Structures

Nanopore-Based Single-Molecule Investigation of DNA Sequences with Potential to Form i-Motif Structures

i-Motifs are DNA secondary buildings current in cytosine-rich sequences. These buildings are fashioned in regulatory areas of the human genome and play key regulatory roles. The investigation of sequences able to forming i-motif buildings on the single-molecule stage is very essential. On this examine, we used ╬▒-hemolysin nanopores to systematically examine a sequence of DNA […]

The WM-q multiple exact string matching algorithm for DNA sequences

The WM-q multiple exact string matching algorithm for DNA sequences

The string matching algorithms are among the essential fields in computer science, such as text search, intrusion detection systems, fraud detection, sequence search in bioinformatics. The exact string matching algorithms are divided into two parts: single and multiple. Multiple string matching algorithms involve finding elements of the pattern set P in a given input text […]